Feasibility Study of Early vs Delayed Extubation in Brain Injured Patients
Author Information
Author(s): Manno Edward M, Rabinstein Alejandro A, Wijdicks Eelco FM, Brown Allen W, Freeman William D, Lee Vivien H, Weigand Stephen D, Keegan Mark T, Brown Daniel R, Whalen Francis X, Roy Tuhin K, Hubmayr Rolf D
Primary Institution: Mayo Clinic College of Medicine
Hypothesis
Is early extubation safe and feasible for brain injured patients who meet extubation criteria?
Conclusion
Recruitment and randomisation of severely brain injured patients appears to be safe and feasible.
Supporting Evidence
- Sixteen patients were randomised between August 2004 and May 2006.
- Five women and eleven men with an age range from 30 to 93 years were enrolled.
- The average delay in extubation for the delayed extubation group was 3.6 days.
Takeaway
This study looked at whether patients with brain injuries could safely be taken off ventilators earlier than usual. It found that doing so seems safe.
Methodology
A single-blinded block randomised controlled trial with 16 patients randomised to early or delayed extubation.
Potential Biases
Potential selection bias due to strict inclusion criteria.
Limitations
The small sample size limits the ability to make definitive conclusions.
Participant Demographics
Five female and eleven male patients aged 30 to 93 years with various neurological injuries.
Digital Object Identifier (DOI)
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