mTOR Pathway and T Regulatory Cells in Nasal Polyps
Author Information
Author(s): Xu Geng, Xia Jiahong, Hua Xiaoyang, Zhou Han, Yu Chuanzhao, Liu Zheng, Cai Kemin, Shi Jianbo, Li Huabin
Primary Institution: Allergy and Cancer Center, Otorhinolaryngology Hospital of the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China
Hypothesis
A hyper-activated mTOR signaling pathway contributes to Foxp3+ Treg insufficiency in nasal polyps.
Conclusion
The mTOR signaling pathway is associated with Foxp3+ Treg insufficiency in nasal polyps, and inhibiting this pathway may enhance Treg expansion.
Supporting Evidence
- Increased infiltration of pmTOR+ inflammatory cells was observed in nasal polyps.
- Foxp3+CD4+ Tregs were significantly decreased in nasal polyps compared to controls.
- Blocking the mTOR pathway with rapamycin increased Foxp3 expression and Treg expansion.
Takeaway
This study found that a certain pathway in our cells, called mTOR, is linked to a lack of special immune cells in people with nasal polyps, and blocking this pathway might help those cells grow better.
Methodology
The study analyzed tissue expression of pmTOR and Foxp3+ Tregs in nasal polyps and controls using histological staining and evaluated the effects of rapamycin on T cell phenotype in a tissue culture system.
Limitations
The study used a tissue culture system, which may not fully replicate in vivo conditions, and lacked ideal models for nasal polyps.
Participant Demographics
{"CRSwNP":{"number":28,"sex_ratio":"16:12","age":"37.7 ± 9.5 (22~56)"},"control":{"number":16,"sex_ratio":"8:8","age":"34.7 ± 11.2 (25~47)"}}
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website