Antibody Response to Sin Nombre Virus in Hantavirus Pulmonary Syndrome Patients
Author Information
Author(s): Pavel Bostik, Jorn Winter, Thomas G. Ksiazek, Pierre E. Rollin, Francois Villinger, Sherif R. Zaki, C.J. Peters, Aftab A. Ansari
Primary Institution: Emory University School of Medicine
Hypothesis
What is the pattern of immunoglobulin class and subclass responses to Sin Nombre virus in patients with hantavirus pulmonary syndrome?
Conclusion
The study found that specific antibody responses to Sin Nombre virus were present in high titers during the early phases of hantavirus pulmonary syndrome.
Supporting Evidence
- 100% of acute-phase samples tested positive for SNV-specific IgM.
- 67% of acute-phase samples tested positive for SNV-specific IgA.
- 97% of samples had IgG3 antibodies, indicating a strong immune response.
- Antibody titers were compared between survivors and deceased patients, showing no significant differences.
Takeaway
When people get sick from a virus called Sin Nombre, their bodies make special proteins called antibodies to fight it, and these antibodies show up really quickly after they get sick.
Methodology
The study tested serum samples from HPS patients for SNV-specific IgA, IgM, and IgG subclass antibodies using enzyme-linked immunosorbent assays.
Limitations
The study design is cross-sectional, which may limit the ability to draw causal conclusions.
Participant Demographics
Patients were hospitalized with hantavirus pulmonary syndrome in 1993.
Statistical Information
Statistical Significance
p > 0.1
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