Genetic Variations in Interleukin-10 and Depression Risk
Author Information
Author(s): Traks Tanel, Koido Kati, Eller Triin, Maron Eduard, Kingo Külli, Vasar Veiko, Vasar Eero, Kõks Sulev
Primary Institution: University of Tartu
Hypothesis
Are polymorphisms in the interleukin-10 gene cluster associated with major depressive disorder (MDD)?
Conclusion
The study found an increased risk for MDD related to the IL20 and IL24 haplotype, suggesting that cytokines may contribute to the disease's pathogenesis.
Supporting Evidence
- None of the selected SNPs were individually associated with MDD.
- The haplotype analysis detected a significantly higher frequency of block 2 haplotype TGC in the patients group compared to healthy controls.
- The overall frequency of the haplotype TGC was only 2.1% in the pooled group of patients and controls.
Takeaway
This study looked at genes related to inflammation to see if they affect depression risk, and found one gene combination that might increase the risk.
Methodology
A case-control association study was performed with seven SNPs from the IL10 gene cluster involving 153 patients with MDD and 277 healthy controls.
Limitations
The small sample size may hinder the detection of small effects.
Participant Demographics
153 patients with MDD (38 males, 115 females; mean age 40.5 years) and 277 healthy controls (70 males, 206 females; mean age 39.4 years).
Statistical Information
P-Value
0.0097
Confidence Interval
1.28–9.32
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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