Roles of Sulf1 and Sulf2 in Mouse Neonatal Survival
Author Information
Author(s): Charles R. Holst, Hani Bou-Reslan, Bryan B. Gore, Karen Wong, Deanna Grant, Sreedevi Chalasani, Richard A. Carano, Gretchen D. Frantz, Marc Tessier-Lavigne, Brad Bolon, Dorothy M. French, Avi Ashkenazi
Primary Institution: Genentech, Inc.
Hypothesis
What are the roles of Sulf1 and Sulf2 in mouse development and neonatal survival?
Conclusion
Sulf1 and Sulf2 are essential for neonatal survival, with overlapping functions that prevent lethality.
Supporting Evidence
- Neither Sulf1- nor Sulf2-deficient mice showed significant developmental flaws.
- Mice deficient in both Sulf1 and Sulf2 exhibited neonatal lethality.
- Loss of viability was associated with subtle developmental defects.
- Sulf1 and Sulf2 play overlapping yet critical roles in mouse development.
Takeaway
Mice need both Sulf1 and Sulf2 to survive after birth; without them, they often die as babies.
Methodology
Mice genetically deficient in Sulf1 and Sulf2 were created and their phenotypes assessed.
Potential Biases
Potential bias in the interpretation of phenotypic outcomes due to the genetic background of the mice.
Limitations
The study primarily focuses on the roles of Sulf1 and Sulf2 without exploring other potential factors affecting neonatal survival.
Participant Demographics
Mice used in the study were of mixed genetic backgrounds including 129/SvEvBrd and C57BL/6.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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