Impact of High Protein Diet during Pregnancy on Offspring's Liver Gene Expression
Author Information
Author(s): Oster Michael, Murani Eduard, Metges Cornelia C., Ponsuksili Siriluck, Wimmers Klaus
Primary Institution: Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany
Hypothesis
The offspring's transcriptomes show short-term and long-term changes depending on the maternal diet.
Conclusion
A high protein diet during pregnancy affects the hepatic gene expression of energy sensing pathways in offspring.
Supporting Evidence
- Maternal high protein intake during pregnancy is linked to changes in offspring's liver gene expression.
- Offspring from high protein diet mothers showed altered energy metabolism pathways.
- Gene expression profiles were analyzed at prenatal and postnatal stages.
Takeaway
Feeding pregnant pigs a high protein diet changes how their babies' livers work, which might affect their health later on.
Methodology
Pregnant German landrace gilts were fed either a high protein diet or an adequate protein diet, and their offspring's hepatic transcriptome profiles were analyzed at various developmental stages.
Potential Biases
Potential bias due to the specific breed of pigs used and the controlled experimental conditions.
Limitations
The study primarily focuses on a porcine model, which may not fully translate to humans.
Participant Demographics
Pregnant German landrace gilts.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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