How Flaviviruses Activate and Suppress the Interferon Response
Author Information
Author(s): Muñoz-Jordán Jorge L., Fredericksen Brenda L.
Primary Institution: Molecular Diagnostics and Research Laboratory, Centers for Disease Control and Prevention, Division of Vector Borne Infectious Diseases, Dengue Branch
Hypothesis
Flaviviruses utilize various mechanisms to modulate the interferon response.
Conclusion
Flaviviruses can evade the host's antiviral response, leading to severe illness despite the presence of interferon.
Supporting Evidence
- Flaviviruses can reduce the expression of interferon-dependent genes.
- RIG-I and MDA5 are crucial for detecting flavivirus infections.
- Flaviviruses can delay the activation of the host's antiviral response.
Takeaway
Flaviviruses like dengue and West Nile can trick our body's defenses, making it hard for us to fight them off.
Methodology
The study reviews various mechanisms by which flaviviruses interact with the host's immune response.
Limitations
The exact mechanisms of how flaviviruses evade detection and the full extent of their interactions with the immune system are still not completely understood.
Digital Object Identifier (DOI)
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