Impaired health-related quality of life in children and adolescents with chronic conditions: a comparative analysis of 10 disease clusters and 33 disease categories/severities utilizing the PedsQL™ 4.0 Generic Core Scales
2007

Impaired Quality of Life in Children with Chronic Conditions

Sample size: 2500 publication 10 minutes Evidence: high

Author Information

Author(s): James W. Varni, Christine A. Limbers, Tasha M. Burwinkle

Primary Institution: Texas A&M University

Hypothesis

How do chronic conditions affect health-related quality of life in children and adolescents?

Conclusion

Children with chronic conditions report significantly lower health-related quality of life compared to healthy children, with varying impacts depending on the specific condition.

Supporting Evidence

  • Children with diabetes reported the best health-related quality of life.
  • Children with cerebral palsy reported the worst health-related quality of life.
  • Parent reports generally aligned with children's self-reports but showed some differences.

Takeaway

Kids with long-term health problems often feel worse than healthy kids, and some conditions make them feel even worse than others.

Methodology

The study analyzed over 2,500 pediatric patients from 10 disease clusters and compared their health-related quality of life using the PedsQL™ 4.0 Generic Core Scales.

Potential Biases

Potential bias due to differences in self-reports from patients and proxy-reports from parents.

Limitations

Small sample sizes for some disease categories may limit the statistical power and generalizability of the findings.

Participant Demographics

Participants included children aged 2 to 18 with various chronic conditions, with a mix of genders and ethnicities.

Statistical Information

P-Value

p<0.05

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1186/1477-7525-5-43

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