Recombinant human activated protein C helps lung injury in sheep
Author Information
Author(s): Kristine Waerhaug, Mikhail Kirov, Vsevolod Kuzkov, Vladimir Kuklin, Lars Bjertnaes
Primary Institution: University of Tromsø
Hypothesis
Does recombinant human activated protein C (rhAPC) reduce oleic acid-induced lung injury in sheep?
Conclusion
rhAPC reduces pulmonary artery pressure and improves oxygenation in sheep with oleic acid-induced lung injury.
Supporting Evidence
- rhAPC counteracted the increase in extravascular lung water index.
- Oxygenation improved significantly in sheep treated with rhAPC.
- The study demonstrated that rhAPC reduced pulmonary artery pressure.
Takeaway
This study shows that a special protein can help sheep breathe better when they have lung problems caused by a fatty acid.
Methodology
Twenty-two yearling sheep were divided into three groups: one received oleic acid and rhAPC, one received only oleic acid, and one was sham-operated. Various hemodynamic and gas exchange measurements were taken.
Potential Biases
Potential bias due to small sample sizes and the short duration of the experiment.
Limitations
The study may have been underpowered to detect differences in all variables, and the observation time was limited to 2 hours.
Participant Demographics
Twenty-two yearling sheep, mean weight 34.3 ± 7.5 kg.
Statistical Information
P-Value
0.07
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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