Comparing Follitropin Alfa and Lutropin Alfa in One Injection
Author Information
Author(s): Michael Alper, Randal Meyer, Chris Dekkers, Diego Ezcurra, Joan Schertz, Eduardo Kelly
Primary Institution: Boston IVF, Waltham, MA, USA
Hypothesis
Does mixing follitropin alfa and lutropin alfa in one injection change their biopotency?
Conclusion
Mixing follitropin alfa RFF and lutropin alfa did not alter the bioactivity of either FSH or LH.
Supporting Evidence
- FSH bioactivities were similar between the individual and mixed solutions.
- LH bioactivities were also similar between the individual and mixed solutions.
- The study used a total of 233 rats for the bioassays.
Takeaway
The study found that combining two hormones into one shot doesn't change how well they work.
Methodology
The study used bioassays to measure ovarian weight and ascorbic acid depletion in female Sprague-Dawley rats after injecting hormone mixtures.
Limitations
Results may not apply to other FSH or LH products not tested in this study.
Participant Demographics
Female Sprague-Dawley rats, aged 22-26 days.
Statistical Information
Confidence Interval
75.5–92.7 for FSH; 78.7–113.8 for LH
Statistical Significance
p > 0.10
Digital Object Identifier (DOI)
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