Evolution of Class I Cytokine Receptors
Author Information
Author(s): Clifford Liongue, Alister C. Ward
Primary Institution: Deakin University
Hypothesis
The evolution of Class I cytokine receptors and their diversification over time.
Conclusion
The majority of diversification of Class I cytokine receptors occurred after the divergence of urochordates and vertebrates, with limited lineage-specific diversification since then.
Supporting Evidence
- Two Class I receptors were identified in sea squirt, while 36 were found in zebrafish.
- The study suggests a massive expansion of Class I receptors occurred between 794 MYA and 476 MYA.
- Phylogenetic analysis confirmed the evolutionary relationships of the receptors.
Takeaway
Scientists studied how certain proteins, called Class I cytokine receptors, have changed over a long time in different animals. They found that most changes happened a very long time ago, and not much has changed since then.
Methodology
Bioinformatics analysis of Class I receptor repertoire in sea squirt and zebrafish.
Limitations
Phylogenetic trees and alignments may be unreliable due to the divergence of Class I cytokine receptors.
Digital Object Identifier (DOI)
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