WISP-1 Enhances Bone Formation by Boosting BMP-2 Activity
Author Information
Author(s): Ono Mitsuaki, Inkson Colette A, Kilts Tina M, Young Marian F
Primary Institution: National Institutes of Craniofacial and Dental Research, National Institutes of Health
Hypothesis
WISP-1 enhances osteogenesis by increasing the activity of BMP-2.
Conclusion
WISP-1 positively influences bone cell differentiation and function by enhancing BMP-2 effects.
Supporting Evidence
- WISP-1 overexpression enhances BMP-2's ability to direct bone marrow stromal cells toward osteogenic differentiation.
- WISP-1 was shown to bind directly to BMP-2, increasing its activity.
- Transgenic mice overexpressing WISP-1 exhibited increased bone mineral density and trabecular thickness.
Takeaway
WISP-1 helps bones grow by making another protein, BMP-2, work better.
Methodology
The study involved transducing bone marrow stromal cells with WISP-1 and BMP-2 adenoviruses and assessing their effects on osteogenic differentiation in vitro and in vivo.
Limitations
The study primarily used a single transgenic mouse line, which may not represent all potential effects of WISP-1.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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