Intestinal Epithelial-Derived TAK1 Signaling Is Essential for Cytoprotection against Chemical-Induced Colitis
2009
TAK1 Signaling Protects the Intestinal Epithelium from Inflammation
Sample size: 8
publication
10 minutes
Evidence: moderate
Author Information
Author(s): Kim Jae-Young, Kajino-Sakamoto Rie, Omori Emily, Jobin Christian, Ninomiya-Tsuji Jun
Primary Institution: North Carolina State University
Hypothesis
Epithelial TAK1 signaling is important for preventing stress-induced barrier dysfunction.
Conclusion
TAK1 signaling in the intestinal epithelium is essential for protecting against injury-induced inflammation.
Supporting Evidence
- Loss of TAK1 significantly increased DSS-induced colitis severity.
- TAK1 deficiency led to increased apoptosis and decreased epithelial cell proliferation.
- TAK1 is essential for the expression of protective factors like IL-6 and COX2.
Takeaway
TAK1 helps keep the gut healthy by stopping damage and inflammation when things go wrong.
Methodology
The study used TNFR1KO/TAK1IEKO mice subjected to DSS to induce colitis and assessed weight loss, intestinal damage, and inflammatory markers.
Limitations
The study primarily focused on a specific mouse model, which may not fully represent human conditions.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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